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Viral bullet aims for cancer cells 1 Citation According to a latest research, a breakthrough in the use of viruses to target and destroy cancer cells has been reported. This is called the oncolytic virotherapy. The research team was led by Dr. John Hiscott of McGill?s Faculty of Medicine and the Lady Davis Institute, along with Dr. John C. Bell and also colleagues from the University of Ottawa and the Ottawa Health Research Institute (OHRI) are a part of this latest research. They have discovered that a variety of compounds called histone, technorati.com
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121 - systemic lupus erythematosus mcqs 1 Citation 1q: best screening test for SLE ? Answer : anti nuclear antibody . 2q: auto antibodies in SLE associated with decreased risk of nephritis and sjogren syndrome ? Answer : anti Ro and anti La .. 3q: auto antibody correlating with depression or psychosis in SLE ? Answer : anti ribosomal protein antibody . 4q : auto antibody in SLE associated with subcutaneous and neonatal lupus ? Answer : anto Ro antibody 5q: auto antibody in SLE correlating with active CNS lupus ? Answer : anti neuronal, technorati.com
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Epigenetics to shape stem cell future 1 Citation ' Epigenetics to shape stem cell future' and ' Cancer is a stem cell issue': 1) Epigenetics to shape stem cell future Everyone hopes that one day stem cell-based regenerative medicine will help repair diseased tissue. Before then, it may be necessary to decipher the epigenetic signals that give stem cells their unique ability to self-renew and transform them into different cell types. The hype over epigenetic research is because it opens up the possibility of reprograming cells. By ma, technorati.com
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Enzyme behind muscular dystrophy unveiled 1 Citation Washington, December 9 (ANI): Scientists at an American research institute claim that they have been successful in reversing the impact of a mutation in the gene coding the protein dystrophin, known to be associated with muscular dystrophy. Dr. Lorenzo Puri and his colleagues at the Burnham Institute for Medical Research say that their study showed , technorati.com
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Large DNA stretches, not single genes, shut off as cells mature 1 Citation Epigenetic finding adds insight on how cells become brain, liver ? and malignant Experiments at Johns Hopkins have found that the gradual maturing of embryonic cells into cells as varied as brain, liver and immune system cells is apparently due to the shut off of several genes at once rather than in individual smatterings as previous , technorati.com
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1 Citation Dr Joel Gottesfeld's lab in La Jolla, California (USA), is also working on heterochromatin modifiers as a potential treatment for FRDA, and Dr Gottesfeld started his talk by referencing a paper published by Richard Festenstein's group in 2003 (Nature) as the inspiration. His own work in California has supported the theory that heterochromatin gene silencing occurs in FRDA. The interaction between the active form of the frataxin gene and the inactive (silenced) form is mediated by enzymes called, technorati.com
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1 Citation Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups from an ?-N-acetyl lysine amino acid on a histone. Its action is opposite to that of histone acetyltransferase. Subtypes HDAC proteins are found in three groups, the first two groups belong to the classical HDACs and their activities are inhibited by trichostatin A (TSA) whereas the third group is a family of NAD+-dependent proteins not affected by TSA. Homologues to all three groups are found in yeast having the n, technorati.com
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1 Citation The Histone Code The Histone Code is hypothesized to be a code consisting of covalent histone tail modifications. Together with other modifications such as DNA methylation it is part of the epigenetic code. Role of histone The main role of histones is in associating with DNA to form nucleosomes, which themselves bundle to form chromatin fibers. They are globular proteins with a flexible N-terminus (taken to be the tail) that protrudes from the nucleosome. Chromatin structure T, technorati.com
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Misread epigenetic signals play role in leukemia 1 Citation A genetic mistake may lead to misinterpretation of the chemical tags that help control gene activity Read the original post: Misread epigenetic signals play role in leukemia, technorati.com
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