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1Related Readings: Dorothea Fiedler, Ph.D. 1 Citation Lecture Series A Genetic Map of the S. cerevisiae Phosphorylation Network Dorothea Fiedler, Ph.D. Post-Doctoral Fellow, Department of Cellular and Molecular Pharmacology University of California, San Francisco Monday, January 12, 2009 4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.) Second Floor, Welch Hall Related Articles: Tamgu?ney, T., C. Zhang, D. Fiedler, K. Shokat, and D. Stokoe. 2008. Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells. Experimental Cell Re, technorati.com
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Secrets to successful workflows for advanced ?Proteomics 2.0? analyses 1 Citation Common PC proteomic software is designed primarily to be easy to use with low throughput and small datasets up to a few 1000 spectra. PC programs like Mascot or other software generally work fine at this scale.However, high-throughput and large-scale analysis (e.g. 100K+ spectra experiments) ? a foundation capability for biomarker discovery, molecular profiling and advanced post-translational modification research, requires a different methodology because of the increased need for sensitivity, n, technorati.com
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Protein Phosphatase Regulatory Subunits 1 Citation Yesterday I introduced the different classes of phosphatases in a previous post. Here I will discuss regulatory subunits, which are important for PP1, PP2A, PP4 and PP6 catalytic subunits.Protein Phosphatases tend to have relatively promiscuous substrate specificity. Therefore the spatial and temporal activation of these enzymes is controlled by regulatory subunits. Among these, the PP1 regulatory subunits are the best characterized. These regulatory subunits may control the subcellular loca, technorati.com
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1 Citation Well in light of being added to two high powered blogrolls (thanks to The Daily Transcript and Pharyngula ), I figured I best start contributing. My doctoral research focused on kinase and phosphatase targeting subunits, so as i alluded to in previous posts on GM and Compartmentalization and I am particularly interested in how targeting can regulate biochemical activities. A classic example of this is the regulation of protein phosphatases. But before I post on that, I wanted to introduce t, technorati.com
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Pseudosubstrate Regulation of Protein Kinases 1 Citation Recently the Hardie lab from Dundee, Scotland published a paper describing the regulation of the AMP dependent protein kinase (AMPK) by a pseudosubstrate. This is another example of a common mechanism for protein kinase regulation. Specificity of protein kinases is partially controlled by the amino acids surrounding the phosphorylation site. In the case of AMPK the consensus sequence is a series of basic and hydrophobic residues at specific intervals. A pseudosubstrate has the same consensus, technorati.com
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PPP1R3A: Muscle Glycogen Protein Phosphatase Regulatory Subunit 1 Citation Protein Phosphatase 1 (PP1) is a widely expressed protein which removes phosphate groups bound to serine/threonine residues of proteins, thereby reversing the actions of protein kinases. The specificity of PP1 is controlled by several regulatory subunits, which direct PP1 to specific locations and substrates. Examination of several PP1 targeting proteins identified a small common peptide motif R/K-V/I-X-F/W , which is present in most targetting subunits (Johnson et al. 1996).One of these targ, technorati.com
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1 Citation NF-?B , Nuclear Factor kappa Bs, are ubiquitous transcription factors involved in responses to cellular stressors such as cytokines , free radicals, UV irradiation, bacterial antigens , and viral antigens . ? action of I?B : actions of NF-?B : family : free NF-?B : I?B : IkappaBalpha : I?B kinase : IKK : NF-?B family : NF-?B/rel : tumors and NF-?B : v-Rel ? Members of the NF-?B family are classified as NF-?B/Rel proteins because they display structural, technorati.com
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1 Citation The pleckstrin homology ( PH ) domain family includes proteins with the PH domain, which is a 100-120 aa module found in a multitude of intracellullar proteins with widepread functions. Many proteins containing PH domains participate in signaling cascades . Other classes of proteins carry a PH domain, including cytoskeletal proteins such as spectrin . The inositol phospolipids are particularly effective in specific binding to PH domains of cellular proteins. Phosphatidyli, technorati.com
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Twitter Ovarian Cancer Updates 1 Citation ?A new imaging technology could give scientists the ability to simultaneously measure as many as 100 or more distinct features in or on a single cell. In a disease such as cancer, that capability would provide a much better picture of what?s going on in individual tumor cells. A Stanford University School of Medicine team led by Cathy Shachaf, PhD, an instructor in microbiology and immunology, has for the first time used specially designed dye-containing nanoparticles to simultaneously image two, technorati.com
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Functional proteomics of protein phosphorylation in algal photosynthetic membranes 1 Citation Oxygenic photosynthesis is a process of capture and conversion of sunlight into chemical energy by photoautotrophic organisms. Plants, green algae and cyanobacteria perform photosynthetic conversion of sunlight into chemical energy in the permanently changing natural environment. For successful survival and growth photosynthetic organisms have developed complex sensing and signaling acclimation mechanisms. The environmentally dependent protein , technorati.com
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