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We have 14 results for Rapamycin.
1'Fountain of youth' drug can extend life by a decade | Mail Online 2 Citations A miraculous 'fountain of youth' drug that could extend people's life spans by more than a decade has been developed by scientists., delicious.comUntil now, scientists have developed just two ways of extending the life span of mammals. One is to tinker with their genes, the other to restrict their diet. Repeated studies have shown that cutting down on calories can make animals and people live longer. They believe rapamycin - which acts on a protein in cells called TOR - may fool the body into thinking that calories are being restricted., delicious.com
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Drug's Epilepsy-prevention Effect May Be Widely Applicable 1 Citation
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Rapamycin, Autophagy, and Longevity 1 Citation
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Autophagy is required for extension of yeast chron... - PubMed Result 1 Citation
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1 Citation Rapalogs may be more effective in combination with other anticancer agents, including chemotherapy and targeted therapies. It is increasingly apparent that the mTOR signaling network is quite complex, and rapamycin treatment leads to different signaling responses in different cell types. A better understanding of mTOR signaling, the mechanism of action of rapamycin, and the identification of biomarkers of response will lead to more optimal targeting of this pathway for cancer therapy., delicious.com
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The NF1 tumor suppressor critically regulates TSC2 and mTOR 1 Citation Loss-of-function mutations in the NF1 tumor suppressor gene underlie the familial cancer syndrome neurofibromatosis type I (NF1). The NF1-encoded protein, neurofibromin, functions as a Ras-GTPase activating protein (RasGAP). Deregulation of Ras is thought to contribute to NF1 development. The critical effector pathways involved in disease pathogenesis are still unknown. mTOR pathway is tightly regulated by neurofibromin. mTOR is constitutively activated in both NF1-deficient primary cells and human tumors in the absence of growth factors. This aberrant activation depends on Ras and PI3 kinase, and is mediated by the phosphorylation and inactivation of the TSC2-encoded protein tuberin by AKT. Findings identify NF1 tumor suppressor as an indispensable regulator of TSC2 and mTOR. Results also demonstrate that Ras plays a critical role in the activation of mTOR in both normal and tumorigenic settings. Data suggest that rapamycin, or its derivatives, may represent a viable therapy for NF1., delicious.com
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Easter Island compound extends lifespan of old mice 1 Citation
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Transplant drug helps mice live longer 1 Citation By Maggie Fox, Health and Science Editor WASHINGTON (Reuters) - An antibiotic pill originally developed to help prevent rejection in organ transplant patients helps mice live longer and might offer a route to fighting age-related disease in people,..., delicious.com
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Technology Review: First Drug Shown to Extend Life Span in Mammals 1 Citation Rapamycin, delicious.com
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Easter Island Compound Extends Lifespan Of Old Mice: 28 To 38 Percent Longer Life 1 Citation
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