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1 | 2 | 3 | NextPotentially Universal Mechanism Of Aging Identified 2 Citations Annotated link http://www.diigo.com/bookmark/http%3A%2F%2Fwww.sciencedaily.com%2Freleases%2F200 8%2F11%2F081126122203.htm, delicious.com
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The Achilles? Heel of Aging § SEEDMAGAZINE.COM 1 Citation "...a proven method to extend life already exists; scientists have known about it since the 1930s. It?s called calorie restriction, or CR. Feed a mouse a nutritious diet that has 30 percent fewer calories, and she lives 30 percent longer than the one in the next cage. Nor is she condemned to an extended, prolonged period of senescence; on less food, she lives longer and better, resistant to age-related diseases.", delicious.com
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1 Citation
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1 Citation good list of links..., delicious.com
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Wistar institute team finds key target of aging regulator 1 Citation Deacetylation of H4K16 by Sir2 and consequent telomere stability play a major role in maintaining long lifespan in yeast. Since sirtuins deacetylate many different proteins, these results clarify a key role of Sir2 protein in control of lifespan., delicious.com
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Next-Generation Longevity Drug Works Mouse Wonders 1 Citation Sirtris Pharmaceuticals was a young company, just 4 years old, when Glaxo bought them in early 2008. They are researching a class of enzymes called Sirtuins, that Glaxo obviously sees as very promising. From the Boston Business Journal: GlaxoSmithKline said the acquisition will allow it to ?significantly enhance its metabolic, neurology, immunology and inflammation research efforts.? In short, the company wanted access to Sirtris? research on Sirtuins, a class of enzymes thought to be inv, technorati.com
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SIRT1 and SIRT2 expression analysis in human CR 1 Citation November 14, 2008 Calorie restriction, Gene expression, Sirtuins As we know, a calorie restriction (CR) diet improves the health and lifespan in animal models. In the ongoing search for human biomarkers to assess the effects of CR in humans, Crujeiras et al. analyzed sirtuin gene expression changes and blood antioxidant markers in obese patients who followed a 30% calorie restricted diet for 8 weeks. The researchers selected two of the seven human sirtuins to study, SIRT1 and SIRT2, becaus, technorati.com
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Has universal ageing mechanism been found? - health - 26 November 2008 - New Scientist 1 Citation
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How Cells Age The Universal Mechanism Of Aging 1 Citation Parallels between mice and yeast uncover a potentially universal aging mechanism The SIRT1 protein long associated with age-related disease, clusters around chromosomes in the nucleus of a mouse cell. In young organisms, SIRT1 effectively doubles as a gene-expression regulator and a DNA repairer. But when DNA damage accumulates?as it does with age?SIRT1 becomes too busy fixing broken DNA to keep the expression of hundreds of genes in check. This process is so similar to what happens in aging yea, technorati.com
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