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11 Citation The MYC proto-oncogene encodes the transcription factor , c-Myc protein, which binds DNA to regulate transcription . c-MYC is the cellular homolog of the retroviral v-myc oncogene, which when altered by chromosomal translocation , or amplification, or when exhibiting deregulated expression, plays a significant role in mutagenesis of tumors including bladder and breast cancers. c-Myc binds with a variety of protein interactors . The c-Myc transcription factor is a helix-loop-helix, technorati.com
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1 Citation Abstract Conclusion: The longer alleles (CA)17-20 of the promoter region of PARP-1 gene may confer some protection against bilateral Meniere?s disease (BMD). Objective: To analyze microsatellite (CA)n polymorphisms in the promoter region of PARP-1 gene and seek out risk and protective variants for BMD. Subjects and methods: Eighty patients from two ethnically defined groups with definite BMD, according to the diagnostic scale of the American Academy of Otolaryngology Head and Neck Surgery, were, technorati.com
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Dentistry Of Future? Gene Responsible For Formation Of Enamel Discovered 1 Citation Image via Wikipedia A team of researchers lead by Dr Thimios Mitsiadis at the University of Zurich, Switzerland, has identified a gene responsible for the formation of enamel, which is the key component of the teeth. The experiments were accomplished in mice carrying a deletion of the transcription factor Tbx1, a gene that plays a principal role in several human malformations (heart, thymus, parathyroid, face, and teeth) associated to the DiGeorge syndrome. ?Subjects afflicted by DiGeor, technorati.com
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Toxicity Mechanism That Causes Parkinson?s Disease Identified 1 Citation Researchers at Emory University School of Medicine have identified a possible toxicity mechanism that causes Parkinson?s disease. Lewy body is abnormal aggregated proteins inside cells. Neurologists have observed in the damaged parts of brains in the patients with neurodegenerative diseases such as Parkinson?s disease for decades. The appearance of Lewy body shows that protein recycling and waste disposal could be the reason that leads to Parkinson?s disease. A study that is going to be publi, technorati.com
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Recommended Readings: Anne Brunet, Ph.D. 1 Citation Special Seminar Series Evolution, Ecology & Developmental Biology Mechanisms of stem cell maintenance during aging Anne Brunet, Ph.D. Assistant Professor, Department of Genetics, Stanford School of Medicine 3:45 pm - Refreshments 4:00 pm - 5:00 pm - Lecture Wednesday, December 17, 2008 Welch Hall, 2nd Floor Recommended Readings: Carter, M. E., and A. Brunet. 2007. FOXO transcription factors. Current Biology. 17(4):R113-R114. Greer, E. L., and A. Brunet. 2008. Signaling networks in agin, technorati.com
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1 Citation The SRC gene is a proto-oncogene that encodes a 60 kDa non - receptor tyrosine kinase , pp60c-src, and is the human homologue of v-Src, the transforming gene of Rous Sarcoma Virus. The cellular c-Src is linked to an array of signaling pathways impacting cellular proliferation , transformation, differentiation , survival, adhesion and migration. Overexpression and activation of c-Src is linked to the development of roughly 50% of human tumors derived from the colon, liver, lung, bre, technorati.com
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1 Citation Sumedha Sumedha talked today about her recent research on biophysics: how to understand transcription factor binding and its relation to how cells operate. The basic question boils down to an interplay of geometry, chemical potential, and the polymer physics (entropy of loops) of say DNA. For simple model systems the outcome is a funny model of random graphs with a link/degree restriction per vertex. Which, can be studied analytically and out comes a percolation transition which can be first or, technorati.com
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Transcription-Factor Mutations and Disease 1 Citation Transcription-Factor Mutations and Disease Correct regulation of gene expression, so that specific proteins are made by the appropriate organs at the appropriate times or in response to specific signals, is essential both to normal development and to the correct functioning of the adult organism. Such regulation is usually achieved at the level of DNA transcription, a process that controls which genes are transcribed into RNA by the enzyme RNA polymerase, although regulation also occurs after, technorati.com
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Gene silencing blocks malaria parasites development in multiple mosquito species 1 Citation Washington, March 14 (ANI): Researchers at the Johns Hopkins Bloomberg School of Public Health have revealed that they have been able to block the development of the malaria-causing parasite in Anopheles gambiae, A. stephensi and A. albimanus mosquitoesthree mosquito species that spread malaria in Africa, Asia and the Americasby silencing a gene called caspar. The , technorati.com
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Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia 1 Citation Neurodevelopmental disorders that disturb speech and language are highly heritable. Isolation of the underlying genetic risk factors has been hampered by complexity of the phenotype and potentially large number of contributing genes. One exception is the identification of rare heterozygous mutations of the FOXP2 gene in a monogenic syndrome characterised by impaired sequencing of articulatory gestures, disrupting speech (developmental verbal dyspraxia, DVD), as well as multiple deficits in expre, technorati.com
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