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Atovaquon + Proguanil (Malarone??) 1 Citation Atovaquon + Proguanil (Malarone??) Definition Atovaquon interferes with the transport of electrons inside the plasmodia, proguanil impairs protein metabolism. The combination of both substances is effective against all forms of malaria. Treatment is carried out for three days. As water solubility of atovaquon is poor, it should be taken with a fatty meal to improve intestinal resorption. Side effects of the drugs are headache, cough and gastrointestinal symptoms (primarily vomiting an, technorati.com
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